The most comfortable, natural action for all people is to twist the hand from the centre to the outside (external rotation). For right-handers, it is a clock-wise twist. For left-handers, it is an anti-clockwise twist. Using a standard corkscrew is not a natural action for lefties and it can be downright uncomfortable. These are becoming less popular with the introduction of screw-cap bottles but there are a number of winemakers still using good old cork.